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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '104d46350bc670c23af6845350f2ad5e5a644369b80410f1674d371f33bf6a56' 
  AND token = 'YmiH4wAImuyZ0Uerc1Qb2IrANjRQghJ3GXHK1DR3aB8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}