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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b43e0ebd83d4b355cc63257c2e1829dee20fb2f7ea47dc00b6a9250477c351c4' 
  AND token = 'K17g/OSPLw55vX30e3p2uzjnnZeTsei0xUZzEhmGKyc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}