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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b12161ba305da12b2be417aca123f748a480585e5fa3613c411a0ef7867fc54' 
  AND token = 'F+UzBCxnvFc5Y1vSBgoNDpvL6MMH+lAXaXRt90Xxw7g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}