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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8b3d63c1175aa439d7bb7b26a9aa7e6d2b760fecb003a0fc1c7b65b880690af' 
  AND token = 'R0JrATOSHaZM3dYzVYrjeBbZdhkYzZyIgxh3ULnAojk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00072

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}