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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33ffc64f267a76f1ee635b0ee77e9df6012936f961374739b95703fcc5d3f1d9' 
  AND token = 'yQUoIUAINE7MNC/Pyp9PTVh6GeBS2Yo7QiEe8uvvR48=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}