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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '728f0d60cd375092f683875a03af34e0f35bd79e8e8ed315479d49b1d2767c74' 
  AND token = 'YZP9xUtfWRXHSkunm388rzjvfMaiqlnkGVMMm0XfRTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}