SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b57cb29c5bc52b89d7be543e5de15bf25bda93704144b4859e80a75f5629dbba' 
  AND token = 'w2ZOQrgZWUp9PSe25hPCRtk1xe1ANW5U+nwUQH8jNmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}