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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd3eb25aac102f3337a4e1030193c6555590005400b3303a5f2bac67fcf09dcb5' 
  AND token = 'uuwQE1Ur2aMjLzMeWImeCzofWOtcv0oM6UNLB1Re+9w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}