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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c7cde8e410a8d017bd735fcc3680d108b5cc8c1d3d115319fbcf22ada376ee22' 
  AND token = 'Aq2gU+rUULEsxkZkktQoMZdt6VfFqFPiliJ+W5PKnkM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}