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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b357ac46ee631aafbe0e57a4a9771378bd0207cb847d2db7984740d08a39f69b' 
  AND token = 'rNQGztSPlMXtXehecGgwwhBSz+fw9KWAMmoW5NEjnWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}