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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5378c99e7148ea5717a317e46c13abd211622efeed6386eb9d57c3de0cd2207' 
  AND token = '1i2F9pP5VHxhOCrlOeXdwmAWpLl8kzWcGYkTb1RZ8r0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00084

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}