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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280463a0e28c33bbdaca35918d9120ddebbffec5eb985fa5ee220f24fcb8862f' 
  AND token = 'wUWdWSTtRf9smL6THhwwMaGwOmcXWCKZTNN7QXZoxWU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}