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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e629b8c32d1efe2fb2aeb57e05e4fc7556a438926be795b401288b1801c20b85' 
  AND token = 'PrIRIxqEL+fp7VEMUk0zuoEBTTQMx+BcVUwKCgEmW1U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}