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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4867cf1527e2e4ed0b1ec4438db7005070ece8d1ba06b65e4d5315558df41ac8' 
  AND token = 'qdwC3+YwLOXAh49n18A7wiDhp8RY3VOMZ/0QzRSfVD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}