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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ea8b5327f3994302bdc56a162176a1806ed4a96eef497ff645df7544daecff04' 
  AND token = 'r+Y5PNiiQtbh3yhRTNzFA3fm9xh+Sje5W8RakmtlaDU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}