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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a7e9b54be173b65ba7dbb4fb8735c77a2edd44d4822db3157651702bde1f448' 
  AND token = 'Xc+KrA2AZhvHPhvXQmtXAFN0ceKh8fL34gKUKS0JK0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}