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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd226264ae36e7a0d42f9884c4c984040f64e7a09792fa3bf87ac4c6eadc95a1b' 
  AND token = 'BGQe9l4VtyF+gssv0Xzg2ZEPA+aazU3V1NoMtN77RLs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}