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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33222954665d2bb21a9bc3c6fec3fe636f6a41b1d66e091f1e4b4d7969b7d749' 
  AND token = 'owTkCmcBDRrccMRuvwqfa71LGMBi8FxI98o1pRR4RcU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}