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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f7d706654ae7c7146d59c80b1afa71333bfec5d646a5c5ba263d0fcfa9cf7f' 
  AND token = 'hOSdzfg33Pe1irifpsLUA2xnwnr0c2L3Z/+PYfHwMHU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}