SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46fc45f1f02bafb11a18ca0272e77b84aaa64446e2cb5c328c5e55d5e14a7b41' 
  AND token = 'wGprNCVajuYjlAmEVBZgZXbKfC4aSyU32SyRGvyLDWQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}