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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52d5ac7e91dd788cb16b4a820bce2d3c7ce9961e2ccd72a1d888733a96c76d55' 
  AND token = 'VA0NKkxv6IecZ+S5KeyqGzLIMCIY8WnNITtPvS2xsa0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}