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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '004515b0bb204c19ba021ee9a28df7ef0d608a6cd8b69b1389897c4668032902' 
  AND token = 'doXSYjEHA8VAYoph1MSKckZCq24LHBsCsbAAyw6icBI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}