SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b069bdb78735b5b5a3a0de1598999ab814f002522be25a6ac0507cbd21b1f43' 
  AND token = 'h9hGmM42z4G2Odc0Nr17k5M9yJZQ8PcX1+2RSrHcQyI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}