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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65cb3f36ca174a0d44b34ff43dddc882684bb3de028121288ccfe5a9f47adaa2' 
  AND token = 'RQwW8Lj7VSlyu9Z2uQHYPDN+23hXoXTkobgICs9m6I8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}