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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a958c6883a0bc3a6885775c492f5a12e669e7a6916bb660f44b880d8a1e74a' 
  AND token = 'zG5I2h2ATdj4wb4YMfUvS1QKQd3LuFRca8N97AYv64Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}