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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b41735ed6d5f295b5286d74c3f4a71fe406ce53d2f21c459e179ba2bfc6f8da' 
  AND token = '7sRu3gTKf6GcQVLiUmwMjK+MzcuRud4V0CNGiDW1GiU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}