SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64d53eccd87e161d0a91d3d50f9621a563b73ebf0c36e3f1689b63763ab7653b' 
  AND token = 'eR0u1LCrV7N49pN1tNavk1A9TgzNvmmpaY7W3Qrh6Xc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}