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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b497cfada4b7edef8668fd9e705f391842b352d42d0813c50a4ac77bc9bf4e8d' 
  AND token = 'xH/MFqbUY503z9eqkp1NGYF9h/fMhBFUlHEqkpqLIFg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}