SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80d9737ada9a40bdb3719fd6de0aa5778287df7652d3f2c60a7b85fc5c854781' 
  AND token = 'NBUtSIfu4m3fXYPyLnGI2XqBiZFFThsVc7JdbT0Qq10=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}