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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43fa17eef6d457471a09db78c15b9bee018ce20bbe4ff70d5610091f50e78561' 
  AND token = 'eSQpJM+cLIY4S4xOTcEkxHcvix9NMHZm/IrooE8Cqb4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}