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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '469ff05e3d363a397e81f91fa1e3d3646444d76fbdc011bb700a360210446e2f' 
  AND token = 'v5wiUXBnCO4iIaOazIkxjKI18XHWWsNFoKo2jcW+GoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}