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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46cb3bdfa0de32030f09a490580927b0cd1c9b9e47781e07f78fec4778210386' 
  AND token = '8FAI3sOoHt2LlYGsg6VKQCS9ASIHhHBVVg9xN1MbLS0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}