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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72022d3715c0c219225e940f13e037c8d985600b840abcbcc78b7259fa73e8c2' 
  AND token = 'QnUdNQBBmjyH+vIwf36tr8b+tXi/8mvqjDYNfKItaxo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}