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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3fd342f4e41059055f2b71242ac55998ad2e642f2fbbe9e4d22f2644ebbcd32' 
  AND token = 'R88eT985IUNRd8XxkOK+4aoo9pYN0OT1JDUh4YXKNI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}