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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9a21e912664eb7a04a1683c8125fb14c4f09b9a60c671118c50dd034822d8627' 
  AND token = 'xoR1Ppt4QE+RlY01geB1zzy3GCgFUeDMZ0pZq5cXizA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}