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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e78880cd1c7ffd5d74c17d14a7b50e05f81c35076b24e7020010987042e6afa9' 
  AND token = 'Il7ZTyerG3LDT36Gkhgg2qFnUXC2dUaff7eImFraTB4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}