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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fdda06f0f6c21702145c0f072a256df8f6b67587dac832cdb5b52369ad942e5' 
  AND token = 'NtNEqCy2x5/CrXVBEOfu5oIUpBLtnDRUN8CqAgImnKM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}