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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '622d8731bc1f7105751a6653fceb6cc14a2633cec4e2a5fdcfefd7078094003d' 
  AND token = 'sfnXDmahzVFKJlN7oMPKf+u9rA7FAwb/0w33dc8Byu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}