SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7d5e714001050346cf24828c829997f48e2ba227124564a7af0929379e54e38d' 
  AND token = 'UyZP57vGEU9ybC+sGDajtmZCm+7+eEbaexUrm4frTIs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}