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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '774e8b69c0a8af128d1d05ca814fb39b1feb7cb5dd8d161e119d27edd9161e2e' 
  AND token = '2H06QrLPpXO2TNG/uHNx3Fdy2+FDxQkp8dA6RYCmrzM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}