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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '70b0d9e4071c42fe35f1847884e721b39981f34d2c024398d0f4b3685c08c075' 
  AND token = 'OPPsT0PcahVmlPkt0Eyuj6yNcRYshKcddd7n0ASMnaE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}