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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39b6bc68c543c42c64038e9d717e1c30780907a33bb9103bc4bdcca86d4874f1' 
  AND token = 'FMLkXe9wdTeoixjCufZ+RXB1FAubxMHIQSjFeOZrDMY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}