SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849000eaaaf0cfcec977c2eb3eabe24ecc8e3e758a923b2592d7a634ba15d976' 
  AND token = 'VNEP1sQZVsZDm+NbCTCpYcHUJcu/PNEH3C3uTzW3Vkg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}