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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '791b8dbf7814c9962b91393a817efb81d6581588ee302b71f1f637d05396a9b2' 
  AND token = 'd/nJ+rTe8ChA7v6q/fpMvVrJpeN+LOj1SbPUC4xkvnc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}