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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c9894abb9af3b6f3ce75dd76f1e29c5359d9d45bde1807717101d26af00e073' 
  AND token = 'NPX1fuMzG+FGDLkVBpwPoGg3tRyHlpr8wt/psNW7e2E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}