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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e78767f7d833ca803ca9470d373441077de1e575cf1e366504000bc0770f135' 
  AND token = 'aO4a6KQiPEoYryjMBVFZ9Ed7edwRawrql/AzpcPt+hE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}