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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c5ea48e78576ceb69e9bda30f41b48518ca1986ea12fdc3053bdf401f853d71' 
  AND token = 'eiHxWF+qBHO9IS3UUOJ/1ArA9bbDLWeU2O47z7xGrC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}