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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18b535e1d4d064b39c17a396d0739012913f171395040693af9395fde41870d6' 
  AND token = 'wMYr1TNfYJv8ekA+oPl1EL+LE++Jq4bkl5Ngnv5+yDU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}