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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c4e89a3a5c7a3500026dacc37f968c865a3c1c87fde6a21405c66bda1d7ce35' 
  AND token = 'f6oE40HltKQ4xyZ1SS5GhW/QO0mmPxKeOdkhfV49qbc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}