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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0863a68d0675d467b0601cf072432899189b3d91f86a986438e8bf6e48f59c5d' 
  AND token = 'w2Q72N+c+xVaTY2w2KZyPjAoWiY2/JgTaP5Ar9tNAPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}